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As with other psychotropic drugs, the same old safeguards with respect to administration of the drug and measurement with the prescription are indicated for seriously frustrated individuals or Those people in whom there is rationale to hope hid suicidal ideation or strategies.
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The First move in alprazolam metabolism is hydroxylation catalyzed by cytochrome P450 3A (CYP3A). Medicine that inhibit this metabolic pathway could possibly have a profound effect on the clearance of alprazolam. Therefore, alprazolam need to be averted in people receiving very powerful inhibitors of CYP3A.
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Flumazenil, a selected benzodiazepine receptor antagonist, is indicated for the complete or partial reversal of your sedative outcomes of benzodiazepines and may be Utilized in predicaments when an overdose which has a benzodiazepine is thought or suspected. Prior to the administration of flumazenil, essential actions really should be instituted to secure airway, air flow and intravenous entry. Flumazenil is meant as an adjunct to, not in its place for, good management of benzodiazepine overdose.